Brad Paisley will return to the Grand Ole Opry on Sept. 23 for a very worthwhile cause. The singer will headline the Opry's Salute to Country Cares, in honor of the 25th anniversary of Country Cares for St. Jude's Kids.

Country Cares for St. Jude's Kids was founded in 1989 by Alabama lead singer Randy Owen. Since its inception, the event has raised more than $500 million to help St. Jude Children's Research Hospital in their ongoing fight against childhood cancer and other illnesses.

“It’s been a very blessed endeavor, and for me, the greatest accomplishment for country music in the last 22 years has been Country Cares for St. Jude Kids,” Owen tells The Boot. “In my eyes, [it's not] CDs sold and all that kind of stuff. When I look at the number of little children that are alive today because of what happened with Country Cares, I think that’s the greatest accomplishment of country radio.”

Other artists who will perform at the Opry's Salute to Country Cares include Eric Paslay, Charlie Daniels and Maddie & Tae. A portion of the proceeds from the evening will go to support St. Jude. Tickets are available for purchase here.

Paisley's latest album, 'Moonshine in the Trunk,' was released last month. He will continue his Country Nation World Tour this month with shows in Virginia and North Carolina. Download 'Moonshine in the Trunk' here, and see all of his upcoming shows here.