Lady AntebellumLady Antebellum is on fire -- winning a pair of CMA Awards, having a multi-week No. 1 album and song, performing on the Grammys and coming home with their first Grammy award. Now they're celebrating another amazing first ... a call from Oprah! The trio is set to make their debut appearance on the Oprah Winfrey Show, live on Friday (Feb. 19).

Lady A will perform a medley of their No. 1 hits, 'I Run to You' and 'Need You Now, as part of 'Oprah Fridays Live' show, where the talk show host chats about the latest news and headlines. They believe the coveted invitation, along with the rest of their success, all goes back to a hit song. "There's nothing more powerful than a No. 1 song or even just a Top 5 song," Lady A's Charles Kelley tells The Boot. "But once a song gets up to a Top 10, that means the fans are responding to it, and so it's special when you know you're connecting with the fans. Then you start seeing in a live show setting, the numbers start to grow and more fans in the seats, you're selling out bigger venues ... to see the tangible effects of it is important."

In other news, the group's current single 'American Honey' is sitting at No. 12 on the country charts, and they're headed back out with Tim McGraw on Friday night in Roanoke, Va.

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